CD40L dependent platelet string formation in the mouse microcirculation in vivo.
University of Heidelberg / University Clinic, Heidelberg, Germany
I got my Bachelor’s degree in Biochemistry with 3rd distinction from University of the Punjab, Lahore, Pakistan in Aug 2011. Later in 2013, I earned my Master’s degree in Genetics and Bioengineering on a foreign scholarship from Fatih University, Istanbul, Turkey with the highest CGPA of 3.94/4.00 in my department. My interest in cardiovascular field started from my Master’s research project namely: “Quantitative PCR analysis of gene expression in endothelial cells exposed to shear stress at branching points in arteries leading to atherosclerosis”. In July 2014, I got an opportunity to join Prof. Hecker’s lab in the department of Cardiovascular Physiology, Heidelberg University and became part of SmArteR network to pursue my career in cardiovascular research. During my PhD, I have successfully completed one project namely: “CD40L dependent platelet string formation in the mouse microcirculation in vivo” in collaboration with Prof. Pohl from Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-University of Munich. We found that the absence of ADAMTS13 enhances the ultra large von-Willebrand factor (ULVWF) multimer-platelet mediated leukocyte recruitment and extravasation in venules which is augmented by CD40L stimulation. The distribution and co-localization of ULVWF multimers and CD40 in venules could contribute to the enhanced leukocyte extravasation there. Currently, I am working on another project for establishing “Dorsal skin fold chamber as a novel model for vessel remodeling and arteriogenesis”.