Prolonged in‐vitro culturing and functional assessment of arteries and application of ex‐vivo cultured arteries as bioreactor facility
LifeTec Group (LTG) B.V., Eindhoven, The Netherlands
In July 2007 I got my bachelor degree in Biotechnology and in July 2009 I got my master degree in Medical and Pharmaceutical Biotechnology, both at the University of Pavia. In July 2013 I got my PhD in Biomedicine at King’s College London, within the “SmArt” programme. The title of my project was: Endothelial lineage differentiation from induced pluripotent stem (iPS) cells is regulated by miRNA-21/AKT and TGFβ2 pathways.I completed my postdoc, as a “SmArter” fellow in March 2016. At LTG I was appointed as Senior Researcher to perform pre-clinical studies on porcine carotid arteries cultured ex vivo in vascular bioreactors. For this project I worked in the R&D process to develop and design long term culture protocols and assays. In the vascular bioreactor I applied physiological hemodynamics in order to keep tissue functionality and viability. Artery segments were cultured under (patho)physiological conditions in a system that allowed application and monitoring of pressure, flow, compliance and wall shear stress. At the completion of my postdoc, I was appointed as Associate Scientist at Merck until September 2016. From September 2016 I am attending a Master in International Health Care Management, Economics and Policy at the SDA Bocconi Business School in Milan, as tuition waiver beneficiary.