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  • Aleksandra Mazur
Dmitry Kamaev


The role of calcium-activated chloride channel ANO1 in the vasculature



Aarhus University, Aarhus, Denmark





The aim of my PhD study was to contribute to understanding of ANO1’s involvement in physiology and pathophysiology of arteries. ANO1 is a calcium-activated chloride channel that is suggested to be important for contractile function of arteries and is known to be involved in several pathological conditions among them experimental pulmonary hypertension and experimental essential hypertension. The study was performed using three different animal models in which expression of ANO1 is altered in arteries.