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  • Aleksandra Mazur
Nikolett Szarka

Project

Changes of vasomotor mechanisms of cerebral vessels in hypertension and stroke.

 

Partner

University of Pecs, Medical School, Pecs, Hungary

 

I graduated in 2011 from the Medical School of the University of Pecs in Hungary. During my university years I started doing research as an undergraduate researcher at the Department of Pathophysiology studying flow-induced response of isolated cerebral arteries. After graduation I spent 4 years in the United States as a research associate at the University of Oklahoma Health Sciences Center studying age-related changes of neurovascular function under the guidance of Dr. Ferenc Deak (a former fellow of the Nobel laureate Dr. Thomas Sudhof). In 2014 I got the opportunity to join the SmArteR network in Hungary as the fellow of Prof. Akos Koller. My project is focused on the changes and adaptive responses of cerebrovascular mechanisms sensitive for hemodynamic forces during stroke and after traumatic brain injury. I perform experiments investigating responses of isolated cerebral vessels (both arteries and veins) using pressure/wire myography and dissect the underlying mechanisms by molecular biological approaches (RNA and expression, assays for detecting cerebrovascular oxidative stress, immunohistochemistry with confocal microscopy).