The role of MAGI1 in integrin-mediated endothelial cell migration and adhesion to the extracellular matrix.
University of Fribourg / Department of Medicine, Fribourg, Switzerland
In 2011, I graduated in Biology at the Complutense University of Madrid. During the last year, I performed my master project in `The Role of RIAM in the function of leukocytes´ within the department of Immunology of the Complutense University of Madrid. After studying for 2 years the syllabus required for Biologists to work in Hospitals in Spain, in 2013 I started a 6-month internship at the institute of Molecular Genetics (IMG) of Prague. During these months, I got experience with molecular biology, especially with CRISPR/Cas9 technology. In 2014, I had the chance to join the SmArteR network at Prof. Curzio Rüegg’s group at the Department of Pathology of the University of Fribourg in Switzerland. My phD project is focused on the role of the protein MAGI1 in the integrin signalling that mediates endothelial cell migration and adhesion to the extracellular matrix during angiogenesis. We overexpress (cDNA) and downregulate (shRNA, CRISPR/Cas9) MAGI1 in HUVEC and perform in vitro functional assays relevant to endothelial cell migration, adhesion and barrier function.